Chikungunya Fever: A Decade of Progress in Epidemiology, Pathogen Diagnosis, Prevention, and Vaccine Development

Abstract

Chikungunya fever is an acute infectious disease caused by the bite of Aedes mosquitoes carrying the Chikungunya virus. This disease has a high incidence rate and significantly impacts public health. Due to climate change and human activities, the infection and global spread of this virus have attracted widespread attention in recent years. Despite a solid research foundation, challenges remain in diagnosis, treatment, and prevention strategies. This article aims to review the latest developments in Chikungunya virus and vaccine research from 2014 to 2024. It provides an overview of the epidemiological characteristics and pathogenic features of Chikungunya fever and systematically analyzes existing treatment and prevention strategies, with a particular focus on progress in vaccine development, including the clinical efficacy of marketed vaccines and recent advancements in research pipelines. The goal is to provide technical support for the prevention and control of Chikungunya fever.