The neuroattenuation of three clone viruses isolated from the attenuated CTN rabies virus

Leitai Shi, Yongxin Yu, Yuhua Li

Abstract


Three attenuated rabies virus strains(CTN181-3，CTN181-16 and CTN181-19), were selected by plaque cloning from CTN-181 rabies attenuated virus，which was infected guinea pigs submandibular glands.After passaging those viruses in suckling mice brain for five consecutive passages or in submandibular gland of guinea pigs for one passage, non-virulence reversion or increase were detected.The neuroattenuation stability make the three newly selected CTN attenuated strains the promising live vaccine candidates for wild animal prophylactic vaccination and even postexposure prophylaxis of rabies for humans.


Keywords


neuroattenuation stability,clone virus, attenuated rabies virus

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Journal of Applied Virology

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.